PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo
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چکیده
منابع مشابه
Antioxidants Inhibit Subsequent Lipid Production via Sebaceous Gland Cell Differentiation
The sebaceous gland is composed of sebaceous gland cells that accumulate intracellular lipid droplets when undergoing differentiation. The extent of lipid droplet formation within the sebaceous gland cells thus represents their differentiation status. On reaching maturity, the sebaceous gland cells are then destroyed and the intracellular lipids are secreted to the skin surface whereby they for...
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Diffuse sebaceous-gland hyperplasia is a rarevariant of sebaceous-gland hyperplasia that isdistinct from the well-known circumscribed type.The term presenile sebaceous hyperplasia has beenutilized to describe this entity that is distinguishedby specific features, which include confluence oflesions that results in the formation of large plaqueson the face, the sparing of periorificial regions, a...
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The principal activity of mature sebaceous glands is producing and secreting sebum, which is a complex mixture of lipids. Sebum composition is different among species and this difference is probably due to the function that sebum has to absolve. In human sebum there are unique lipids, such as squalene and wax esters not found anywhere else in the body nor among the epidermal surface lipids. Mor...
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An otherwise healthy 38-year-old woman sought treatment for a right-sided progressively enlarging submandibular mass of 3 years’ duration. No significant personal or family history of malignancy was noted. The mass was initially measured as 2 × 1 cm. Three years later, on palpation, the mass was over the right submandibular area and was measured as 4 × 3 cm. It was soft and movable without tend...
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Tumors produced by 2-acetylaminofluorene occur with differing frequencies in various organs. The squamous-cell carcinomas of the auditory canal region, reported in the original experiment of Wilson, De Eds, and Cox (23), appear to be of particular interest. There has been considerable discussion in the literature as to their site of origin and mode of development. In our experiment this type of...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2013
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2013.05.016